本专题征集关于人类早期发育中非整倍体的原创研究,重点关注胚胎活力、染色体嵌合体以及植入前遗传学检测。专题强调对人类配子和胚胎开展的分子细胞遗传学和细胞基因组学分析,并从实验、计算和临床多个角度,综合探讨减数分裂与有丝分裂错误、染色体不稳定性以及早期谱系特化等问题。
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This Collection invites original research on aneuploidy in early human development, focusing on embryo viability, chromosomal mosaicism, and preimplantation genetic testing. It highlights molecular cytogenetic and cytogenomic analyses of human gametes and embryos, integrating experimental, computational, and clinical perspectives on meiotic and mitotic errors, chromosomal instability, and early lineage specification.