本专题聚焦于基于质量源于设计(QbD)原则的人工智能/机器学习驱动的制剂设计,以及用于定制化剂型的3D打印和静电纺丝纳米纤维。内容涵盖刺激响应平台(超声触发递送、金属有机框架材料)和用于靶向释放的先进纳米载体(胶束、脂质体、聚合物、脂质体、混合型)。特别关注下一代疗法——siRNA、反义寡核苷酸、CRISPR/Cas和PROTACs,以及用于非侵入性治疗的鼻内脑部递送。
This Collection spotlights AI/ML-driven formulation design under QbD principles, alongside 3D printing and electrospun nanofibers for customizable dosage forms. It covers stimuli-responsive platforms (ultrasound-triggered delivery, MOFs) and advanced nanocarriers (micelles, liposomes, polymeric, lipid, hybrid) for targeted release. Special focus includes next-gen therapeutics - siRNA, antisense oligonucleotides, CRISPR/Cas, and PROTACs-plus intranasal brain delivery for non-invasive approaches.