本专题论文集重点阐述了调控骨骼肌干细胞在发育、稳态、再生、衰老和疾病过程中命运的内在分子机制。它汇集了多项研究,揭示了转录、表观遗传、转录后调控、翻译和代谢机制如何调控干细胞的静止、激活、自我更新和分化,以及这些过程的紊乱如何导致衰老和肌肉疾病中的再生能力下降。
This Collection highlights the intrinsic molecular programs that govern skeletal muscle stem cell fate during development, homeostasis, regeneration, aging, and disease. It brings together studies that uncover how transcriptional, epigenetic, post‑transcriptional, translational, and metabolic mechanisms regulate stem cell quiescence, activation, self‑renewal, and differentiation, and how disruption of these processes drives regenerative decline in aging and muscle diseases.