本专题探讨癌细胞可塑性作为肿瘤进展、复发和耐药性的驱动因素。重点关注适应性和可逆状态的改变,包括耐药性、非遗传耐药性和谱系重编程,以及肿瘤微环境的影响。我们欢迎采用单细胞、空间、谱系追踪和纵向研究方法开展的机制研究和综述,以及针对适应性细胞状态和预防复发的策略。
This Collection explores cancer cell plasticity as a driver of progression, relapse, and therapy resistance. It highlights adaptive and reversible state changes, including drug tolerance, non-genetic resistance, and lineage reprogramming, and the influence of the tumor microenvironment. We welcome mechanistic studies and reviews using single-cell, spatial, lineage-tracing, and longitudinal approaches, as well as strategies to target adaptive cell states and prevent relapse.